FGFR3 Knockout mouse

FGFR3 Knockout mouse

Категория Встреча
Дата проведения 14 - 16 января 2020
Организатор Brady Marcia
Место проведения США, 45-1 Ramsey Road, Shirley, NY 11967, USA: 45-1 Ramsey Road, Shirley, NY 11967, USA На карте
Контактное лицо Brady Marcia
Контактный телефон 6316197922
Контактный E-mail contact@creative-biogene.com
Сайт www.creative-biogene.com/crispr-cas9/solution/fgfr3-gene-editing.html
ID в системе 289000005616
Адрес в сети Бизнес Онлайн bizon.ru/289000005616
Fibroblast growth factor receptor 3 (FGFR3), also known as CD333, is a tyrosine kinase receptor located on the cell membrane and belongs to the FGFR family. The FGFR3 gene is located on human chromosome 4 at p16.3 and contains 19 exons, expressing several slightly different isoforms. FGFR3 protein structure comprises an extracellular structure with 2 or 3 immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. When the extracellular portion binds with FGF, FGFR3 dimerizes and autophosphorylates and then triggers a downstream signaling cascade that ultimately affects cell growth, migration, angiogenesis, and differentiation.