HDAC1 Gene Editing

HDAC1 Gene Editing

Категория Встреча
Дата проведения 15 - 23 января 2020
Организатор Brady Marcia
Место проведения США, 45-1 Ramsey Road, Shirley, NY 11967, USA
Контактное лицо Brady Marcia
Контактный телефон 06316197922
Контактный E-mail contact@creative-biogene.com
Сайт www.creative-biogene.com/crispr-cas9/solution/hdac1-gene-editng.html
ID в системе 289000005618
Адрес в сети Бизнес Онлайн bizon.ru/289000005618
HDAC1 forms a complex with BRG1, RB1 and negatively regulates CREST-mediated resting neuronal transcription. After calcium stimulation, HDAC1 is released from the complex, recruiting CREBBP and promoting transcriptional activation. Recent studies have shown that HDAC1 is a molecular switch between neuronal survival and death. Its interaction with HDRP promotes neuronal survival, while interaction with HDAC3 leads to neuronal death. And the germline deletion of HDAC1 can lead to mouse embryonic lethality before embryonic period 10.5.