HDAC1 forms a complex with BRG1, RB1 and negatively regulates CREST-mediated resting neuronal transcription. After calcium stimulation, HDAC1 is released from the complex, recruiting CREBBP and promoting transcriptional activation. Recent studies have shown that HDAC1 is a molecular switch between neuronal survival and death. Its interaction with HDRP promotes neuronal survival, while interaction with HDAC3 leads to neuronal death. And the germline deletion of HDAC1 can lead to mouse embryonic lethality before embryonic period 10.5.